DUAL WAVELENGTH SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF DROTAVERINE HYDROCHLORIDE AND ACECLOFENAC IN THEIR COMBINED TABLET DOSAGE FORM

摘要

A.simple,.accurate.and.precise.dual.wavelength.spectrophotometric.method.was.developed.for.simultaneous.determination.of.Drotaverine.hydrochloride. and. Aceclofenac.in. combined. pharmaceutical. dosage.form..The.principle.for.dual.wavelength.method.is."the.absorbance.difference. between. two. points. on. the. mixture. spectra. is. directly. proportional. to. the. concentration. of. the. component. of. interest".. The.wavelengths.selected.for.determination.of.Drotaverine.hydrochloride.were.271.5.nm.and.280.0.nm,.whereas,.the.wavelengths.selected.for.determination.of.Aceclofenac.were.301.5. nm.and. 311.0.nm..Methanol. was. taken.as.a.solvent..Regression. analysis.of.Beer's.plots. showed.good.correlation.in.concentration.range.of.8‐32.μg/ml.for.Drotaverine.hydrochloride.and.10‐40.μg/ml.for.Aceclofenac..Accuracy.of.method.was.found.between.98.33‐101.5%..The.precision.(intra‐day,.inter‐day.and.repeatability).of.method.was.found.within.limits..The.proposed.method.was.successfully.applied.to.determination.of.these.drugs.in.commercial.tablets..