Synthesis Of 3-Substituted-6, 8-Dibromo-2-Methyl Quinazolin-4(3H)-One Derivatives Via 6, 8-Dibromo-2-Methyl-4h-Benzo [D] [1,3] ?Oxazin-4-One.

摘要

The condensation of methyl 3, 5-dibromoanthranilate with acetic anhydride yielded the cyclic compound 2-Methyl-6, 8-dibromo-4H-benzo-oxazine-4-one which further produce a novel 2, 3-disubstituted quinazolin-4-ones via the reaction with hydrazine hydrate. The compounds synthesized were unequivocally confirmed by means of infrared, Nuclear Magnetic Resonance (1H and 13C), Gas chromatography Mass Spectrophotometer and Elemental analysis.