Role of carboprost in prevention of postpartum hemorrhage

摘要

Background: Postpartum hemorrhage (PPH) is one of the most common causes of maternal death throughout the world. Pregnancy and childbirth involves significant health risks, even to women with no preexisting health problem. The objective of this study was to analyze the role of carboprost in prevention of PPH. Methods: This prospective observational study was conducted in the department of obstetrics and gynaecology of Dr. Sushila Tiwari Memorial Hospital, Haldwani, Uttarakhand, India. A total number of 100 cases delivering in the labour room that fulfilled the selection criteria were included. Carboprost 250 microgram (1 ml) was administered intramuscularly to each of the case just after the delivery of the anterior shoulder of baby. Duration of third stage, amount of blood loss, incidence of PPH and side effect profile was studied. Results: Carboprost reduces the duration and amount of blood loss in the third stage of labour but is associated with a number of unpleasant side effects. Conclusions: Active management of third stage of labour is recommended in all cases. Carboprost is highly efficacious in reducing the incidence of PPH.