Methods of induction of labor in intrauterine fetal demise: a comparative study

摘要

Background: This study was undertaken to evaluate and compare the efficacies of two different regimen for induction of labour in IUFD in an effort to find a better management of woman with IUFD. Methods: It was a hospital based prospective comparative study taken up in the Department of Obstetrics and Gynaecology, Assam Medical College and Hospital (AMCH), Dibrugarh for a period of 1 year. A total number of 90 cases were selected and randomly divided into 2 groups. The two groups were induced using regimen recommended by the RCOG. Group A was induced with Mifepristone - Misoprostol Combined Regimen while Group B was induced with only Misoprostol. Results: Both the groups were found to be comparable with respect to mean Pre – induction Bishops score. The mean Induction to Onset of Labour Interval and Induction to Delivery Interval were significantly less in Group A as compared to Group B. Mean dose of Misoprostol required was less in Group A compared to Group B. In terms of side effects tolerance to Group A was better than Group B. Conclusions: It was observed in the study that both the regimen were equally safe, easy to administer and affordable but the Combination Regimen had a slight edge over misoprostol alone regimen in terms of tolerance, fewer side effects and efficacy with regard to early onset of labour, shorter Induction to Delivery Interval and relatively less dose of misoprostol than misoprostol alone regimen.