Evaluation of triglyceride: HDL-C ratio and Non-HDL-C as harbingers of increased cardiovascular risk in metabolic syndrome

摘要

Background: Metabolic syndrome is an aggregate of conditions that together increases the risk of developing cardiovascular disease and type 2 diabetes mellitus. Dyslipidemia consisting of elevated triglyceride, decreased HDL, and altered triglyceride to high density lipoprotein- Cholesterol (TG/HDL-C) ratio is useful in predicting cardiometabolic risk and insulin resistance. The present study aimed to compile further evidence for clinical utility of TG/HDL-C ratio and Non HDL-C as simple, cost effective tools for early identification of cardiovascular disease risk in metabolic syndrome. Methods: This study was carried out with hundred subjects. Fifty of these subjects were diagnosed with metabolic syndrome according to National Cholesterol Education Program Adult Treatment Panel III; while other fifty were age and gender matched healthy control subjects. Results: The impact of cardiometabolic markers on metabolic syndrome was assessed separately in men and women by applying Mann Whitney ?U? test. Study showed highly significant increase in TG, HDL, TC/TG and TG/HDL-C ratio in women compared to men with p