Clinical Utility of CA125 Levels in PredictingLaparoscopically Confirmed Salpingitis in PatientsWith Clinically Diagnosed PelvicInflammatory Disease

摘要

Objective:The purpose of this study was to determine the utility of serum CA125 determinations indiagnosing acute salpingitis.Methods:CA125 levels were determined for 34 women with the clinical diagnosis of pelvicinflammatory disease (PID). Acute salpingitis was confirmed laparoscopically in 28 women (82.3%).Results:Twenty patients (71.4%) with laparoscopically confirmed acute salpingitis had CA125levels greater than 7.5 units, compared with no patients (0/6) with laparoscopically normal tubes (P= 0.002). The degree of elevation of CA125 levels correlated with the severity of tubal inflammationnoted at laparoscopy. All patients with levels above 16 units had laparoscopically severe salpingitis.Conclusions:We conclude that while CA125 levels above 7.5 units may modestly improve theability of the clinical diagnosis of PID to accurately reflect visually confirmed acute salpingitis,limitations of the test make its clinical utility questionable.