Many patients have difficulty in swallowing tablets or hard gelatine capsules and consequently do not take medication as prescribed especially in case of paediatric and geriatric patients. The objective of present study is to provide a taste masked suspension of macrolide antibiotic i.e. erythromycin using the ion exchange resins which can deliver a Pharmaco- kinetically and Pharmaco- dynamically acceptable dosage form. In the present investigation the bitter taste of erythromycin is masked by using three different resins i.e. Indion-204, Doshion-p-542 and Kyron -T-114. A number of formulations have been prepared by using different ratio of resin with drug i.e.1:1, 1:2 and 1:3 for suitable combination along with a control formulation. The prepared formulation has been evaluated by using the different parameters such as particle size, pH, sedimentation volume, taste, color, In-vitro drug release and stability studies. These studies concluded that our prepared taste masked oral suspension of erythromycin Estolate S7 is easily redispersibility and at pH 1.5 has cumulative % of drug release is 98.1±0.06 within 60 minute. Moreover, the taste evaluation of prepared formulation has been evaluated through spectroscopic methods and palatable evaluation and thereby the macrolide antibiotic could be masked taste for the patient’s compliance.
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