Comparative Pharmacokinetic and Relative Bioavailability Study of Ursodeoxycholic Acid Tablets in Healthy Indian Volunteers”

摘要

The present study was aimed to synthesize a series of novel 5-(1,3-benzthiazol-2-ylamino)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3- thione and to evaluate their in-vitro anti-inflammatory activity and in vitro on panel of 60 different human tumor cell lines derived from nine neoplastic cancer types at NCI. The compounds were evaluated using inhibition of bovine serum albumin denaturation method have shown significant in-vitro anti-inflammatory activity. The findings of present study clearly demonstrate that chloro functional group possess inhibition of bovine serum albumin denaturation capacity and has in-vitro anti-inflammatory activity. However methoxy and dimethyl derivatives show mild to moderate in-vitro anti-inflammatory activity. The compounds were evaluated at single concentration of 10-5 M towards the panel of 60 cancer cell lines derived from nine different cancer types: leukemia, lung, colon, CNS, melanoma, Ovarian, Renal, prostate and breast cancer at NCI. The compound 7a, 7b, 7f shows moderate anticancer activity. Structural assignments are based on spectroscopic data (FT-IR, 1H NMR, MASS spectra).