Nanoemulsion in Ophthalmics: A Newer Paradigm for Sustained Drug Delivery and Bioavailability Enhancement in Ophthalmic Manifestations

摘要

Patient noncompliance to dosage regimen is one of the most challenging aspects to achieve therapeutic target for ocular diseases. Simplifying regimen characteristics for ophthalmic dosage forms by reducing frequency of dosing is one the prime alternative to achieve patient compliance. For ophthalmic dosage forms, precorneal, corneal and blood ocular barriers, in addition to frequent washouts, prevent the penetrability of therapeutic agents and hence multiple daily dosing is required. Multicomponent nanoemulsions are thermodynamically stable and easily manufactured systems that provide better penetrability and reduced frequency of dosing of formulations with improved solubility and stability. Also micellar characteristics of nanoemulsion systems mimic tears that enhances adherence of therapeutic agents to corneal tissues. Particle size (<200 nanometer) makes the system easy to sterilize by filtration and further helps with improved visibility compared to eye ointments and oleaginous formulations. Current review focuses nanoemulsion system for sustained drug release and enhanced bioavailability for better patient compliance in ocular therapeutics.