The Possible Protective Effect of Bupropion (0.5%) Eye Drops Against Selenite Induced Cataract in Rabbits”

摘要

In this study, the n-butanol extract of Genista ulicina Spach was evaluated for its antioxidant properties and for its hepatoprotective effect against Chlorpyrifos-Ethyl (CPF) toxicity. The effect of n-butanol extract of Genista ulicina at the dose (100 mg/kg) was studied on Chlorpyrifos-Ethyl induced hepatic damage (20 mg/kg) by gavage for 10 days in Wistar Albinos rats. The liver marker enzymes, aspartate transaminase (AST), alanine transaminase (ALT) and lipid peroxidation (MDA) were estimated to access liver damage. Severe alterations in all biomarkers were observed after CPF treatment. CPF induced hepatic dysfunction revealed by a significant elevated in serum enzymes, AST, ALT and alkaline Phosphatase relative to control values. It was found that combined Genista ulicina (100mg/kg) extract and CPF treatment decreased significantly TBARS, AST, ALT and alkaline Phosphatase level compared to the CPF group (p<0.01). The results of in vivo experiments showed that the n-butanol extract of Genista ulicina inhibited lipid peroxidation and protected the experimental animals from CPF-induced hepatic toxicity.