Azadirachta indica (Neem) Gum Coated Gold Nanoparticles as Nano-go-karts to Dispatch Haloperidol across Blood-Brain-Barrier

摘要

Here efforts to develop a nano sized delivery systems that can cross the blood brain barrier to deliver anti-schizophrenic drug Haloperidol, is reported. Chemically synthesized gold nano particles of 20-22 nm diameter, coated with peptides of Azadirachta indica (Neem) Gum were used as carrier of Haloperidol. Neem gum coated gold nano particles were highly stable and did not need any linker for attachment of the drug. The drug loading efficiency was found to be 92%. So far as drug release kinetics is concerned initially for first 3 hrs there was a burst of drug release and after 24 hrs sustained release of Haloperidol for a period of 168 hrs was noted. The drug release profile of Haloperidol under physiological conditions followed Higuchi model, suggesting that the drug release is through diffusion. Moreover, Haloperidol showed unidirectional diffusion through the matrix of NG which is used to coat Gold Nano Particles.