Formulation Development and In vitro Evaluation of Clarithromycin Topical Gel

摘要

Utility of gel based drug delivery systems are being employed in recent past for therapeutic effectiveness of topical applied drugs. Clarithromycin is a novel macrolide antibiotic. Topical route for Clarithromycin was selected up to avoid GIT irritation and to maximize the drug concentration at the site of action. In the present study an attempts were made to formulate and evaluate topical gels of Clarithromycin. Estimation of Clarithromycin was done in pH 5.5 phosphate buffer spectrophotometrically at 205nm showed good correlation coefficient. All the prepared gels were evaluated for their appearance, pH, drug content, homogeneity, spreadability, SEM, in vitro release. Visually, formulated Hydroxy Propyl Cellulose gels were sparkling and transparent. The pH range of formulated Hydroxy Propyl Cellulose gels was found to be suitable for topical application. The drug content of formulated gel was found in the range of 99.61. The viscosity measurement was done for selected gels using Brookfield viscometer at room temperature and found good consistency. The spreadability of formulated Hydroxy Propyl Cellulose gels was found to be good. The in vitro release was carried out using dialysis membrane in pH 5.5 phosphate buffer. The in vitro drug release was plotted according to release kinetics, to precisely know the mechanism involved in the drug release. Among all gel formulations the drug release was greater in formulation F4 -99.65±0.86.