SYNTHESIS AND ANTI-MYCOBACTERIAL ACTIVITY OF SOME NOVEL ANACARDIC ACID DERIVATIVES FROM CASHEW NUT SHELL LIQUID

摘要

Synthesis and anti-mycobacterial activity of some novel derivatives of anacardic acid emviz/em., 2-Ethoxy-6-pentadecyl benzamide (APHK-1), 1-(2-methoxy-6-pentadecylbenzyl)-4-hydroxy ethylpiperazine (APHK-2), 1- (2-hydroxy-6-pentadecyl)- N- (hydroxyl ethylaminoethyl) benzamide (APHK-3) and compounds 20-34 from saturated anacardic acid which was obtained from natural product cashew nut shell liquid (CNSL) is reported. Anti-mycobacterial activity was performed using emMycobaterium smegmatis/em mcsup2 /sup155, taking anacardic acid and ethambutol as standards. Of all the derivatives, 1-(2-hydroxy-6-pentadecyl)-N-(hydroxyethylaminoethyl) benzamide exhibited good anti-mycobacterial activity.