A CASE STUDY ON RUBIA CORDIFOLIA L IN FILM COATING OF TRIPHALA GUGGLE AYURVEDIC TABLETS

摘要

Alizarin [1, 2 di hydroxy anthraquinone] is the major pigment, extracted from Rubia Cordifolia L. The aim of the present work is to extract manjith dye and alizarin pigment from Rubia Cordifolia L., and use it in the film coating of triphala guggle ayurvedic (TGA) tablet. The optimum extraction conditions for manjistha dye are 600C and 60 minute stirring with methanol (80%) and M:L ratio(1:10) with particle size 0.50mm. Separation and purification of alizarin was carried out by column chromatography. The purified alizarin was characterized by UV-Vis, and FT-IR, techniques. Acetylation of alizarin has been carried out with acetic acid in presence of sulphuric acid. Coating offers many benefits namely, improving asthetic qualities of dosage forms, masking unpleasant odour or taste, easy ingestion, and improving product stability. In the present study core tablets of triphla guggul are coated with manjistha extract, manjistha dye, pure alizarin, and acetylated alizarin. After coating, the stability of tablets were evaluated at regular intervals. The purpose of the stability testing is to provide proof of how the quality of a finished product varies with time under the influence of a variety of environmental factors such as temperature, humidity and light. These studies are conducted at 40°C±2°C/75% ± 5% RH in a humidity chamber noted for significant changes occurs at any time during six months. Organoleptic characteristics and physico-chemical parameters were calculated to check the efficacy of tablets.