Efficacy of Subgingivally Delivered Flurbiprofen and Chlorhexidine Chip in the Treatment of Chronic Periodontitis – A Randomized Controlled Clinical Trial

摘要

Antimicrobial and pharmacologic agents delivered locally in the periodontal pocket modulate the host response and enhance the effect of non-surgical periodontal therapy. The aim of present randomized controlled clinical trial was to determine the efficacy of multiple applications of subgingivally delivered Flurbiprofen and Chlorhexidine chip in patients with chronic periodontitis. 50 patients suffering from chronic periodontitis were randomized into groups A and B. Following scaling and root planing, patients were treated by subgingivally delivered Flurbiprofen or chlorhexidine chip. The chips were re-inserted sub-gingival at weeks 1, 2, 3, 5 and 7 if PD > 5mm. Clinical parameters including Plaque index, Gingival index, Papillary Bleeding Index, Probing depth and Clinical attachment level were recorded at baseline,1, 3 and 6 months. Data analysis was carried out using SPSS package (Ver 10.5). Both the therapeutic approaches led to significant reductions in PI, GI, PBI, probing depths and greater gain in CAL compared to baseline over a period of 6 months (p < 0.001). Difference in mean PD reduction and CAL gain from baseline to 6 months in between the groups was 0.36 ± 0.333mm which was not statistically significant. The combination of SRP and subgingival delivery of flurbiprofen or chlorhexidine chip was more effective than SRP alone in improving the clinical parameters. Furthermore, frequent applications of CHX or FBP chips resulted in greater mean PD reduction and CAL gain than single application.