A STUDY OF ANTICONVULSANT ACTIVITY OF ALCOHOLIC EXTRACT OF LEAVES OF PASSIFLORA INCARNATA ON MICE

摘要

Leaves of P. incarnata were powdered and subjected to successive extraction with solvents like ethanol, methanol and water using soxhlet apparatus. All the extracts were administered as suspension in water for injection in all the experiments. Preliminary phytochemical investigation of the AELPI (alcoholic extract of leaves of Passiflora incarnata) revealed the presence of alkaloids, glycoside and flavonoids. It was found to be non-toxic even up to the dose level of 2000mg/kg [LD50]. In PTZ induced convulsion models medium and high doses 200 and 400mg/kg. Anticonvulsant effect of high dose 400mg/kg was found to be better than the medium dose 200mg/kg. In MES induced convulsion model medium and high doses 200 and 400mg/kg but not the low dose 100mg/kg of AELPI had exhibited significant anticonvulsant effect by decreasing the duration of tonic-extensor phase and increasing the latency of clonus convulsion. Thus the result recorded with above experimental models confirms the anticonvulsant activity of AELPI. The present investigation revealed that, the AELPI possessed anticonvulsant activity.