STUDY THE EFFECT OF PROCESS VARIABLES IN FLUID BED GRANULATION ON THE PHYSICO-CHEMICAL PROPERTIES OF GRANULES

摘要

The purpose of this research was to improve the granulation efficiency and the final granule characteristics for the any kind of the material that is to be granulated via FBG process. The fluid bed granulation process is an influenced by various processing parameters like atomization pressure, binder addition rate, in let temperature etc. These process variables largely affect the granulation efficiency and the final granule characteristics. The effect of starting materials on granule properties was previously studied. The aqueous solution of 5% PVP K-30 was used as a binder and sprayed on lactose monohydrate bed. A full factorial design was applied to optimized the granulation process variables like inlet air temperature, spray rate and batch size and other granule properties, namely the Carr's index, Hausner index, the angle of repose and the moisture content, were evaluated at the optimal operation conditions. Granules prepared by this technology have good flow property, good compressibility; and good flow ability with a proper adjustment of process variables. So FBG technique has its own importance for the granulation purpose in the pharmaceutical industry and technology