SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME NOVEL IMIDAZOLIDINE ANALOGUES AS POTENT ANTIDIABETIC AGENT

摘要

Imidazolidine are five-member heterocyclic compounds having two nitrogens in the ring. There are two carbonyls in the ring, one of them between the two nitrogens. The five positions of the ring are numbered and, as such, there are four points of functionality, one at the 1 position, one at the 3 position and two at the 5 position in their ring structure respectively and thus exhibiting potent as well as wide range of pharmacological activities. A series of, phenylene methylene hydantoin were synthesized. Benzaldehyde derivatives reacted with imidazolidine to yield the respective derivatives. This reaction follows the Knoevenagel condensation reaction mechanism by which ethanolamine abstract a proton from heterocyclic ring and a carbanion ion is generated. The structure of synthesize compounds were supported by IR, NMR and mass spectral data. The synthesized compounds were screened for their in vitro antidiabetic activity by α-amylase, α-glucosidase inhibition, glucose diffusion inhibitory test and the potential compounds tested for in vivo activity by blood glucose changes in type 2 diabetic rats.