Epigenesis of Carcinogenesis as Inflammatory Cytokine Mechanics

摘要

Epigenesis in malignant evolution would transform mechanics of development of genetic mutationin terms of failure of DNA repair pathways. Genetic instability would be an expressed result of the developmentof mutagenesis that includes such failed DNA repair mechanisms. The cytokine/chemokine axis of influencein terms of carcinogenesis might particularly implicate proliferation of cells and infiltration of stroma involvingalso targeted action of trophic factors. Epigenesis would be an expression of a malignant transformation eventthat incorporates various modes of evolution in DNA mutagenesis. DNA mutations that develop as multiplepathways of impaired subsequent mutational repair mechanisms would both account for and extend theinfluence of genetic instability systems in carcinogenesis. One might recognize a full array of mechanisticevents inherent to a concept of transformational processes both originating and subsequently promotingvarious systems of tropism and trophism even as the cellular clonality is itself extended beyond the initialcarcinogenetic focus.