The Influence of prolonged |[beta]|-blockers treatment on male rabbit's sexual behavior and penile microcirculation

摘要

The aim of the study was to assess the effect of the prolonged intake of three -blocking drugs (propranolol, metoprolol and nebivolol) on the sexual behavior and penile microcirculation of rabbits. Drugs were administered p.o. for 9 weeks and every three weeks in each group (n=13) one subgroup (n=7) performed behavioral tests, whereas in the second subgroup (n=6) penile microcirculation was measured with a laser Doppler flowmeter. The copulation studies revealed significant impairment of sexual function only in the propranolol treated group. The measured behavioral parameters suggest that at a given dose propranolol affects more performance rather than arousal aspects of rabbits' sexual behavior. In the course of the whole study no significant difference was observed among groups in penile blood flow. The data indicate that among the -blockers given only propranolol interferes with sexual behavior, and that -blockers do not appear to have a negative effect on penile microcirculation.