Hepatoprotective Effect of Royal Jellies with Different Harvesting Time on CCl 4 -Induced Liver Damage in Rats

摘要

Liver damage, both acute liver injury and chronic liver damage, can lead to liver fibrosis and cirrhosis. Studies have suggested that royal jelly (RJ), the vital food for queen honeybee development, is able to boost lipoprotein metabolism and lower both the serum total cholesterol (TC) and the low-density lipoprotein (LDL) levels. At 7 days after the mice were administered royal jelly as a hepatoprotective agent against paracetamol-induced liver damage, it was determined that RJ has a marked protective effect on liver tissue. Based on this information, we can ascertain that RJ may be beneficial in the treatment of liver damage. Therefore, the aim of this study was to investigate the protective effect of RJ on CCl 4 liver injury in male SD rats, and to compare the protective effect of royal jelly at different harvest times. The harvest times of royal jelly on CCl4-induced liver injury had no significant effect on LFTs, liver biological index and gross pathology, but the changes of SOD, GSH, T-AOC, LPO and MDA in liver injury caused by CCl4 were significant. Moreover, 72 h RJ had better protective effect than the 48 h harvested royal jelly.