Effect of Telmisartan in Experimentally Induced Diabetetes Mellitus in Rats

摘要

Background: Increased oxidative stress is involved in the pathogenesis of diabetic nephropathy and neuropathy. Angiotensin IIis a know factor in the pathogenesis of diabetic complications. The protective effects of ACEIs is known in diabetic nephropathy.Thus, Angiotensin receptor antagonists may have the same role. In this study, possible antidiabetic effect of Telmisartan and itstissues antioxidant effect in (STZ) induced diabetic rats, were studiedMethods : The present study was done on 40 rats. They were divided into 2 main groups. Group I: 10 rats as control group,received distilled water. Group II: 30 rats subdivided into 3 equal subgroups as follow: Subgroup IIA: control diabetic group,received 55 mg/kg STZ intraperitoneally. Sub group IIB: diabetic rats, received 10 mg/kg telmisartan daily intragastrically.Sub group IIC: diabetic rats received 10mg/kg gliclazide daily intragastrically. Diabetes was induced by intraperitoneal injectionof 55 mg/kg STZ for 8 weeks evidenced by significant increase in serum glucose, HBA1c and decreased Hb levels.Results : Diabetic rats showed a significant increase in tissue TBARs and a significant decrease in tissue (GSH) and (SOD)enzymes. Telmisartan or Gliclazide in diabetic rats produced a beneficial effect on serum glucose, Hb, HBA1c and restoredtissue GSH and SOD with a fall in tissues TBARS.Conclusion : Telmisartan might be proved useful in the treatment of diabetes and its complications, as Gliclazide is restrictedby its secondary failure rate and side effects.PDFHow to Cite Hamed, A., & Malek, H. (1). Effect of Telmisartan in Experimentally Induced Diabetetes Mellitus in Rats. International Journal of Health Sciences, 1(2). Retrieved from https://ijhs.org.sa/index.php/journal/article/view/98More Citation FormatsACMACSAPAABNTChicagoHarvardIEEEMLATurabianVancouverDownload CitationEndnote/Zotero/Mendeley (RIS)BibTeXIssueVol 1 No 2 (1): Issue 2SectionOriginal Paper Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).Make a SubmissionInformationFor ReadersFor AuthorsFor LibrariansIndexed in PubMed, PubMed Central, EBSCO Host, Emerging Sources Citation Index (Thomoson Reuters), DOAJ, Google Scholar, Microsoft Academic