COMPARATIVE DOCKING STUDIES ON GLUTATHIONE S TRANSFERASE (GALLUS GALLUS) WITH ANTI-APOPTOTIC LIGANDS (HOMO SAPIEN)

摘要

Anti-apoptotic proteins play a vital role in deactivating the apoptosis process in cancer disease. Apoptosis process can be activated in cancer state by inhibiting anti-apoptotic proteins. Apoptosis occurs via 2 main signaling pathways the Intrinsic and Extrinsic pathways. Extrinsic pathway is regulated by p53 protein, cyt c and apaf-1 regulates the intrinsic pathway. A class of caspase cascades (2, 3, 6, 7, 8, and 9) helps in induction, transduction, amplification and execution of apoptotic signals in intrinsic and extrinsic signaling pathways. Comparative docking studies are done on the anti-apoptotic proteins which disclosed their interaction energies. Henceforth anti-apoptotic proteins were chosen to perform docking studies which are assumed that the inhibitors/chemical ligands can activate apoptosis process which may proceed to inhibit cancer cells uncontrolled proliferation.