ASSOCIATION OF MEAN PLATELET VOLUME WITH ANDROGENS AND INSULIN RESISTANCE IN NONOBESE PATIENTS WITH POLYCYSTIC OVARY SYNDROME

摘要

Background: Mean platelet volume (MPV) is generally accepted as a new marker of cardiovascular disease risk in several studies.Objectives: This study aimed to determine the association of MPV with androgen hormones and insulin resistance (IR) in nonobese patients with polycystic ovary syndrome (PCOS).Patients and Methods: A total of 136 patients with newly diagnosed reproductive-age PCOS (regarding the criteria of new PCOS phenotypes, based on the Rotterdam criteria) who were nonobese with the mean age of 25 years (25.39 ± 5.51) and mean body mass index (BMI) of 21 kg/m2 (22.07 ± 2.13) were included. In addition, 59 healthy subjects with mean age of 26 years (22.07 ± 2.13) and mean BMI of 22 kg/m2 (21.52 ± 3.84) were recruited as control. Total blood count (including MPV), total testosterone, free testosterone, dehydroepiandrosterone-sulfate (DHEAS), and androstenedione levels were recorded. IR was calculated from blood chemistry measurements of fasting insulin and glucose according to updated homeostasis model assessment.Results: No differences were observed in mean MPV values between patients and control group (9.02 fL (8.5-10.1) and 8.9 fL (7.7-9.1), respectively, P=0.777). MPV values were similar among nonobese patients with and without IR and control subjects (P>0.05). We detected significantly lower values of MPV in patients with hyperandrogenemia in comparison to patients with normal androgen levels (8.7 and 9.5 fL, P=0.012). There was a negative correlation between total testosterone, DHEAS, and MPV (P=0.016, r=-0.229, and P=0.006, r=-0.261, respectively). Multiple logistic regression analyses confirmed the independence of these associations.Conclusions: Our study revealed that nonobese women with and without PCOS have similar MPV values. While IR does not have any effect on MPV, elevated androgen levels are associated with a low MPV in nonobese patients with PCOS.