Direct and Sensitive Determination of Atropine Sulfate at Polymer Electrode in Presence of Surface Active Agents

摘要

A novel, selective, rapid and simple electrochemical method is demonstrated for the first time for thedetermination of atropine sulfate, using poly (3, 4-ethylene-dioxythiophene) (PEDOT) electrode filmmodified platinum electrode in presence of sodium dodecyl sulfate (SDS). The modified electrodedisplays an obvious increase in the peak current (8 times) compared to the bare platinum electrode (Pt).The results indicate that PEDOT/Pt electrode in presence of SDS remarkably enhances theelectrocatalytic activity towards the oxidation of Atropine sulfate. Cyclic voltammetry (CV), linearsweep voltammetry (LSV), and Electrochemical impedance spectroscopy (EIS) are used to verify thevoltammetric behavior of Atropine sulfate in micelles media. Simultaneous determination of Atropineand morphine, and selective determination of atropine sulfate in presence of codeine, ascorbic acid anduric acid are obtained with high sensitivity and good resolution. The PEDOT/Pt in presence of SDShas also been successfully applied to the determination of Atropine sulfate in atropine sulfate injection-1 -1 in the linear ranges of 0.1 to 0.8 mol L and 2.5 to 100 mol L with low detection limits of 27 and64 nM, respectively. The results indicate that the PEDOT/Pt electrode can successfully be applied forthe analysis of pharmaceutics in biological fluids.