Electrochemical Characterization of Oxaprozin on Bare Gold Electrode and Electrode Modified with Bovine Serum Albumin

摘要

As the very first electrochemical investigation of oxaprozin, nonsteroidal anti-inflammatory drug,-3 using cyclic voltammetry on gold electrode in 0.05 mol dm NaHCO3, the synthesized drug, itsanalytical standard and its content in Duraprox tablets were characterized with one oxidation reactionand the three reduction reactions. All they exhibited the linear concentration dependency of anodiccurrents at 0.83V for the analytical standard and 0.85V for Duraprox tablets in the range of-6 -3 concentrations 8.44 32.7810 mol dm . The strong adsorption of bovine serum albumin (BSA) on-3 gold electrode in 0.1 mol dm phosphate buffer solution (pH 7.4) is shown and concentrationdependency of anodic currents of oxaprozin standard on BSA / Au is studied. Following the Langmuiradsorption thermodynamic equation, the binding constants of oxaprozin on BSA / Au electrode was5 3 -1 calculated with the results 1.2310 dm mol .