Conductometric and Spectroscopic Determination of Mebeverine Hydrochloride and the Solubility Products of its Ion Recognition Species

摘要

Conductometric and spectroscopic determination of Mebeverine hydrochloride (MVH), a widely usedantispasmodic, with two precipitating reagents; phosphomolybdic acid (PMA) and silver nitrate(AgNO3) has been investigated. Exploiting the conductometric procedure, the equilibrium constantsand other functions associated with the process of precipitating MVH were determined. Moreover, twonew maneuvers towards equivalence point detection were carried out. In this itinerary, data processingwas performed applying numerical derivatization (first and second derivatives) and Boltzmannalgorithm. The newly prescribed techniques were found to be more reasonable compared to theclassical routine in terms of impartiality and rationality. The described procedures allowed thedetermination of MVH within the range of 2-15 mg using PMA and 1-20 mg using AgNO3respectively. The molar ratio and as confirmed by the molar conductance mole ratio plots, reveal that(1:1) (drug: reagent) ion associates are formed for both reagents with MVH. Furthermore, theprecipitate obtained by ion pairing MVH with PMA has been spectroscopically characterized using IR1 and H-NMR. The method was further applied successively to pharmaceutical formulations containingMVH and the results obtained were favorably compared with those obtained using the official method.