Synthesis and Characterization of Magnetic Nanostructured Lipid Carriers (mNLCs) for Drug Delivery

摘要

Magnetic nanoparticles (MNPs) are a class of nanoparticles, which can be manipulated using magneticfields. Currently, MNPs are recognized as one of the most important mode as a drug carrier while theycan also be potentially used as carriers for gene delivery. In this article, magnetic nanostructured lipidcarriers (mNLCs) are prepared through co-precipitation method. The particle size and zeta potential,structure and thermal properties of the MNPS have been studied. The produced MNPs were alsohydrophobically modified with a long chain of fatty acid namely lauric acid. These modified MNPswere mixed with nanostructured lipid carriers (NLCs) to form mNLCs. The heat capacity and flow ofmNLCs was profligate in the presence of a magnetic field which is a worthy attribute for targeted drugdelivery applications.