Prognostic value of soluble cluster differentiationantigen 14 subtype and platelet activatingfactor in patients with septic shock

摘要

Objective: The aim of this study was to observe and evaluate differential diagnosis and the prognosticvalue of serum soluble cluster differentiation antigen 14 subtype (sCD14-ST) and platelet activating factor (PAF)in septic shock. Methods: From February 2015 to February 2017, 15 patients with septic shock, 20 patients withsevere sepsis, and 30 patients with sepsis, in Jiaozhou People’s Hospital, were enrolled in this study. In the sameperiod, 30 healthy subjects were selected as the control group. Serum levels of sCD14-ST, PAF, procalcitonin (PCT),C reactive protein (CRP), and white blood cell count (WBC) were measured upon patient admission. Acute physiologyand chronic health status II (APACHE-II) scores were also calculated. Differences in each indicator amongthose groups were compared. Correlation between sCD14-ST, PAF, and APACHE-II scores was analyzed. Receiveroperating characteristic curve was used to compare values of various inflammatory markers in diagnosis of septicshock. Results: Levels of sCD14-ST, PAF, PCT, CRP, and WBC as well as scores of APACHE-II in patients with sepsis,severe sepsis, and septic shock were significantly higher than those in the healthy control group (all P0.05). Levelsof sCD14-ST and PAF in patients with septic shock were significantly higher than in patients with severe sepsisand sepsis (all P0.05). Levels of sCD14-ST and PAF in patients with septic shock were positively correlated withAPACHE-II scores. Multiple Logistic regression analysis showed that increase in APACHE-II scores, sCD14-ST, andPAF was an independent risk factor for death of patients with septic shock. Conclusion: sCD14-ST and PAF can beused as diagnostic indicators of septic shock and can monitor prognosis of sepsis.