The Participation of Cell Adhesion Molecules in Cancer Progression: a Recent Review

摘要

Cell Adhesion Molecules (CAMs) are proteins found on the surface of the cell and are responsible for binding to components of the extra cellular matrix or to receptors on other cells. CAMs are highly essential for cell proliferation, and differentiation, as well as migration. There are four important families of CAMs, namely Integrins, Cadherins, Selectins and the Immunoglobulin Super family (IgSF). Integrins are involved in the metastasis of cancer cells and angiogenesis. Selectins are vital to inflammation and the progression of cancer. Cadherins play a prominent role in tumor growth. Members of the IgSF are involved in the inflammation process. CAMs play critical roles in the progression of cancer. Novel approaches can be developed using a combination of cytotoxic and Heparin-based drugs to treat malignant tumors.