Biological effects of antiretroviral drugs in patients VIH positive of the national Centre of Blood donors in Abidjan (Cote d’Ivoire) Gender and age groups analysis

摘要

HIV is a dynamic field, it is crucial to understand the latest advances in ARV therapy. Data regarding new drugs and their combinations continue to emerge, changing standards of practice. In order to assess the effects of antiretroviral drugs on the local population, a descriptive study was conducted on seven therapeutic combinations. The patients studied were selected from the patients infected with HIV, who started treatment at National Center of Blood Donors in Abidjan, C.te d'Ivoire. These patients received regular treatment for 36 months, blood samples were taken every 6 months, clinical and laboratory assessments were performed. All patients were infected with HIV-1 type. Biological parameters analyzed showed positive impact of the treatment characterized globally by the increase of the number and the percentage of CD4. The analysis according to the gender and the age groups didn't show a marked difference. The value of the number and the percentage of CD4 at the end of the treatment were around 400cells/mm3 and 35% respectively. The treatment did not show toxic effect on the liver and the kidney measured through the rate of creatinine and transaminases (TGO, TGP). The gender and the age groups didn't have any influence on these parameters. These positive effects could explain the use of these therapeutic combination in the treatment of HIV positive patient in the National centre of blood donors in Abidjan.