EVALUATION OF ANTIULCER ACTIVITY OF MAANKOMBU PARPAM (SIRUNGI BHASMA)

摘要

Normal 0 false false false MicrosoftInternetExplorer4 Gunmam (Ulcer) is one of the major diseases found in all the socio economic class and perhaps one of the most distressing diseases. The cause of ulceration in patient is mainly due to hyper secretion of Hcl ,pepsin, infection of H. Pylori and also caused by stress and anxiety. In Siddha system of medicine a number of preparations have been used for the treatment of Gunmam . The Maankombu parpam (Sirungi Bhasma -(SB)) has been used for the treatment of gastrointestinal disorders. In view of this, in present study we have to evaluate the anti-ulcer activity of SB. Study was carried out, by using pyloric ligation method in Wister albino rats . SB has significantly decreased free-acidity, total-acidity, ulcer index and gastric volume and significantly increased the pH in pylorus ligated model. Cyto-protective action may be the major mechanism responsible for the present study which cause the generation of prostaglandins promoting inhibition of ulcer. This study shows that SB has the potential to be used as an anti-ulcer drug.