Effect of 25-hydroxy Vitamin D and Hemodialysis on Vitamin D Axis in Sudanese Renal Failure Patients

摘要

Objective: The aim of this study is to investigate the effect of hemodialysis on vitamin D axis through measuring the blood level of25-hydroxyvitamin D, parathyroid hormone (PTH), calcium and phosphate in renal failure patients before and after dialysis compared to their level in healthy subjects. Materials and Methods: 16 Sudanese patients with renal failure under hemodialysis and vitamin D dose and 16 healthy subjects were involved in this study after informed consent. Results: The mean of the 25-hydroxyvitamin D concentration in the control, pre dialysis and post dialysis were 0.75, 1.31, and 0.84 μmol/l sequentially. There was no significant difference between the control and post dialysis samples (p-value = 0.44) and there was significant difference between the means of the control and pre dialysis samples (p? 0.000) and between the pre dialysis and post dialysis samples (p? 0.000). The means of phosphate concentration in the three samples were 3.31, 6.26 and 3.19 mg/dl respectively. Regarding the results of the parathyroid hormone (PTH) and calcium; the means of the PTH in the control, pre dialysis and post dialysis samples were 18.08, 18.01 and 21.96 pg/ml. Concerning the means comparisons, there was no significant difference between all the means. The means of calcium of the three groups were 10.58, 9.96 and 10.14 mg/dl. However, there was no significant variation between the means. Conclusion: 25-hydroxyvitamin D treatment caused significant increase in the blood concentration of 25-hydroxyvitamin D and phosphate and an insignificant decrease in PTH and calcium.