The use of a pH-dependent and Non pH-dependent Natural Hydrophobic Biopolymer (Landolphia owariensis latex) as Capsule Coating Agents in in vitro Controlled Release of Metronidazole for Possible Colon Targeted Delivery

摘要

Summary: Orally administered metronidazole often requires just a fraction of the administered dose for optimum local activity in the colon. Any formulation design that can target drug to the colon may require dose reduction while improving therapeutic act