CONTROLLED RELEASE PHARMACEUTICAL PREPARATIONS BUOYANT IN GASTRIC JUICES; PREPARATION CONTAINS PH-DEPENDENT SALT OF POLYURONIC ACID AND HYDROCOLLOID GELLING AGENT AND IS FREE OF CA++

摘要

A buoyant controlled release pharmaceutical powder formulation is provided which may be filled into capsules and releases a pharmaceutical of a basic character at a controlled rate regardless of the pH of the environment, which formulation includes a basic pharmaceutical, up to about 45% by weight of a pH dependent polymer which is a salt of alginic acid, such as sodium alginate, up to about 35% by weight of a pH-independent hydrocarbon gelling agent having a viscosity of up to about 100,000 centipoises in 2% solution at 20 DEG C and excipients.