PHYTOCHEMICAL, ANTIBACTERIAL AND ANTICANCEROUS ACTIVITY OF CURCUMA PSEUDOMONTANA PLANT EXTRACT (HILL TURMERIC)

摘要

The present study has been designed to evaluate phytochemical, antibacterial and cytotoxic activities of Curcuma pseudomontana plant extract. In the phytochemical screening of Methanolic extract of Curucuma pseudomontana, different tests are performed to find the phytochemicals that are present so as to subject the plant for further medicinal uses. These chemical constituents are mainly responsible for various biological activities. Present work reports for the antibacterial activities of C. pseudomontana plant, dried samples were sequentially extracted with many solvents. Methanol, chloroform, petroleum ether and water extracts of plant showed considerable antibacterial activity against Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Staphylococcus aureus. The in-vitro anticancer activity of methanolic extract was performed by MTT assay method against HeLa cell line. Effect of inhibition of cell growth showed significant cytotoxicity against methanolic extracts showed considerable inhibition (80–90%) of HeLa cell lines. The present study concluded that the methanolic extract of Curucuma pseudomontana possess the phytochemical analysis content of reducing and non- reducing sugars, amino acids, saponins are in good concentration in case of dry plant sample. Thus, it can be inferred that fresh plant sample are richer in their phytochemicals compared to the dried, powdered plant sample and the methanolic extract of Curucuma pseudomontana possess potent antibacterial activities.