The transdermal route of drug delivery has gained great interest of pharmaceuticalresearch, as it circumvents number of problems associated with oral route of drug administration. Themajor barrier in transdermal delivery of drug is the skin intrinsic barrier, the stratum corneum, theoutermost envelop of the skin that offers the principal hurdle for diffusion of hydrophilic ionizablebioactives. Recently, various strategies have been used to augment the transdermal delivery of bioactives.Mainly, they include iontophoresis, electrophoresis, sonophoresis, chemical permeation enhancers,microneedles, and vesicular system (liposomes, niosomes, elastic liposomes such as ethosomes andtransfersomes). Among these strategies transferosomes appear promising.Transfersomes possess aninfrastructure consisting of hydrophobic and hydrophilic moieties together and as a result canaccommodate drug molecules with wide range of solubility. Transfersomes can deform and pass throughnarrow constriction (from 5 to 10 times less than their own diameter) without measurable loss. This highdeformability gives better penetration of intact vesicles. They can act as a carrier for low as well as highmolecular weight drugs e.g. analgesic, anesthetic, corticosteroids, sex hormone, anticancer, insulin, gapjunction protein, and albumin
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