OXIDATIVE STRESS WITH HOMOCYSTEINE, LIPOPROTEIN (A) AND LIPID PROFILE IN DIABETIC NEPHROPATHY

摘要

Diabetic nephropathy is the single most common disorder leading to renal diseases.Reactive oxygen species (ROS) play a major role in the development of diabetic nephropathy.Nephrotic syndrome is often manifesting in progression of diabetic nephropathy. Therefore, thisstudy was carried out to investigate oxidant and antioxidant status in diabetic nephropathypatients. The blood samples were analyzed for quantitation of malondialdehyde as index of lipidperoxide, vitamin C, total antioxidant capacity, homocysteine, lipoprotein (a) and lipid profile.Significantly increased levels of serum total cholesterol, triglycerides, low density lipoprotein,malondialdehyde as index of lipid peroxide, lipoprotein (a), homocysteine (p<0.001) anddecreased levels of serum total antioxidant capacity, total protein, albumin, high densitylipoprotein & plasma vitamin C (p<0.001) were noticed in the patients with diabetic nephropathyas compared to control subjects