Alteration of Locomotor Function and NT-3 and Trk C Expression in the 14th day post-Spinal Cord Injury Rat and Effect of Different Electro-acupuncture

摘要

Purpose: To investigate the influence on the expression ofNeurotrophin 3(NT-3) and Tyrosine Kinase Receptor C(Trk C)in the 14th day post-Spinal Cord Injury(SCI) rats which hadhad different electro-acupuncture(EA) treatment, to elucidatethe possible role of NT-3 and Trk C in the development ofexperimental SCI and the effect of different EA for them.Methods: Adult male Sprague-Dawley(SD) rats were randomlydivided into normal control group(n=12), sham operationgroup (no operation, without SCI nor treatment, n=12), SCImodel group (SCI-induction without treatment, n=12), pulsedEA group(SCI-induction with pulse-EA treatment, n=12), andmusic EA group(SCI-induction with music-EA treatment,n=12). SCI modelwas established by using the modified Allen’smethod. Basso-Beattic- Bresnahan(BBB) scale was performedto assess the locomotor function of rats. The expression ofNT-3 and TrkC was detected by using Western blot.