Electroacupuncture therapy ameliorates motor dysfunction via brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor in a mouse model of Parkinson's disease

摘要

Regionally increased brain perfusion in the Parkinson’s disease with mild cognitive impairment compared to the cognitively normal Parkinson’s disease Parkinson’s disease (PD) has been traditionally characterized as movement disorder, but most patients develop mild cogni- tive impairment (MCI) while upto 80% of these patients develop dementia within 10 years of follow-up period. The neural under- pinnings of cognitive deficits in PD are poorly understood. We have previously used brain FDG-PET to identify the spatial pat- tern of brain glucose metabolism associated with PD dementia which included hypometabolism in the caudate nucleus, tem- poral regions and mid/posterior cingulate (Ko et al., 2017). In the current study, we investigated the pseudo-continuous arte- rial spin labeling (pCASL) magnetic resonance imaging (MRI) data from 15 non-demented PD patients. Cognitive performance was assessed by Montreal Cognitive Assessment (MoCA). Statistical parametric mapping analysis revealed significant negative corre- lation between MoCA scores and pCASL-based perfusion in the right superior temporal area, orbitofrontal area, putamen and mid cingulate area. No brain regions showed positive correlation. The regions showed negative correlation were partially overlapped with the previously identified PD dementia-related hypometabolic regions, potentially suggesting an inverted-U-shape neural activity changes.