Acute amyloid β (25–35 and 1–40) effects on oscillatory activity and synaptic plasticity in the CA3–CA1 circuit of the hippocampus

摘要

STC in retinal network to better understand visual encoding system of retinal network. Persistent gamma spiking in SI non-sensory fast-spiking cells predicts perceptual success Gamma oscillations (30-55 Hz) are hypothesized to temporally coordinate sensory encoding, enabling perception. However, fast- spiking interneurons (FS), a key gamma generator, can be highly sensory responsive, as is the gamma-band local field potential (LFP). How can FS-mediated gamma act as an impartial temporal reference for sensory encoding, when the sensory drive itself pre- sumably perturbs the pre- established rhythm? Combining tetrode recording in SI barrel cortex with controlled psychophysics, we found a unique FS subtype that was not sensory responsive, and spike with regular intervals most concentrated in the gamma-range (Gamma Regular Non-Sensory FS, grnsFS). Successful detection was predicted by a further increase in gamma regular spiking of grnsFS, persisting from before to after sensory onset. In contrast, LFP gamma power negatively predicted detection, and did not cohere with gamma-band spiking by grnsFS. These results suggest that a distinct FS subtype mediates perceptually relevant oscillations, independent of the LFP and sensory drive.