Suppression mechanisms of high frequency electrical stimulation on seizure-like events in rat hippocampal microelectrode array recordings

摘要

Suppression mechanisms of high frequency electrical stimulation on seizure-like events in rat hippocampal microelectrode array recordings Rationale: The hippocampus plays an important role for seizure generation as well as comorbid memory dysfunction in mesial temporal lobe epilepsy (mTLE) patients. Especially, the entorhinal cortex (EC) has been reported as an important neural pathway con- necting the hippocampus to the neocortex, and an important region for the initiation of seizure-like events (SLEs). Recently, our group reported that EC could be the main target to stop or reduce seizures using high frequency stimulation (HFS). In this study, we investi- gated the effects of HFS stimulating the EC during the hippocampal seizures, and elucidated how HFS alters neuronal dynamics involv- ing seizure generation and propagation in entorhinal-hippocampal systems.