The potent psychomotor, rewarding and reinforcing properties of 3-fluoromethamphetamine in rodents

摘要

Cell-based screen using Tet-Off model of amyloid expression reveals novel compounds targeting disease-associated protein aggregates Nuclear aggregates of disease proteins dysregulate cellular functions, thereby causing neuronal cell loss in diverse neurode- generative diseases. Although many in vitro or in vivo studies of protein aggregate inhibitors have been performed, a therapeu- tic strategy to control nuclear aggregate toxicity has not been pursued in depth. In this study, we established a tetracycline (Tet)-inducible nuclear aggregate (b23) expression model to screen potential lead compounds inhibiting nuclearb23-induced toxicity.