rodent, cd47 polypeptide, isolated rodent cell or tissue, rodent entrepreneurial stem cell, rodent embryo, and methods of producing a rodent, grafting human cells into a rodent, evaluating efficacy therapy of a drug directed to human cells and to evaluate the pharmacokinetic properties, to evaluate the specific and unspecific toxicity of a drug directed to human cd47.

摘要

Non-human animals, methods and compositions for producing and using them are provided, wherein said non-human animals comprise a humanization of the gene of an endogenous differentiation (cd) cluster, in particular a humanization of a cd47 gene. said nonhuman animals may be described, in some embodiments, as having a genetic modification to an endogenous cd47 gene such that said nonhuman animals express a cd47 polypeptide that includes a human portion and a nonhuman portion (e.g., a murine portion).