OBJECTIVE: To study the influence of immune and nonimmune risk factors on the development of allograft vasculopathy after cardiac transplantation. METHODS: We studied 39 patients with a mean age of 46±12 years. The following variables were analyzed: weight (kg), body mass index (kg/m2), donor's age and sex, rejection episodes in the first and second years after transplantation, systolic and diastolic blood pressures (mmHg), total cholesterol and fractions (mg/dL), triglycerides (mg/dL), diabetes, and cytomegalovirus infection. The presence of allograft vasculopathy was established through coronary angiography. RESULTS: Allograft vasculopathy was observed in 15 (38%) patients. No statistically significant difference was observed between the two groups in regard to hypertension, cytomegalovirus infection, diabetes, donor's sex and age, rejection episodes in the first and second years after transplantation, and cholesterol levels. We observed a tendency toward higher levels of triglycerides in the group with disease. Univariate and multivariate analyses showed statistically significant differences between the two groups when we analyzed the body mass index (24.53±4.3 versus 28.11±4.6; p=0.019). CONCLUSION: Body mass index was an important marker of allograft vasculopathy in the population studied.
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机译：目的：研究免疫和非免疫危险因素对心脏移植后同种异体血管病发展的影响。方法：我们研究了39例平均年龄为46±12岁的患者。分析了以下变量：体重（kg），体重指数（kg / m2），供体的年龄和性别，移植后第一和第二年的排斥反应，收缩压和舒张压（mmHg），总胆固醇和分数（毫克/分升），甘油三酸酯（毫克/分升），糖尿病和巨细胞病毒感染。通过冠状动脉造影确定同种异体血管病变的存在。结果：在15名（38％）患者中观察到了同种异体血管病变。两组之间在高血压，巨细胞病毒感染，糖尿病，供体的性别和年龄，移植后第一和第二年的排斥反应以及胆固醇水平方面均没有统计学上的显着差异。我们观察到该疾病组中甘油三酸酯水平升高的趋势。当我们分析体重指数时，单因素和多因素分析显示两组之间的统计学差异显着（24.53±4.3对28.11±4.6; p = 0.019）。结论：体重指数是同种异体移植血管病变的重要标志。
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