Purpose: The aim of this study was to evaluate tear osmolarity, tear film function, and ocular surface changes in patients with psoriasis. Methods: At a single center, 30 eyes of 30 patients with psoriasis (group 1) and 30 eyes of 30 healthy individuals (group 2) were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer I test, tear film break-up time (TBUT) test, scoring of ocular surface fluorescein staining using a modified Oxford scale, and tear osmolarity measurement. Results: Tear osmolarity values, OSDI, and Oxford scale scores were significantly higher in group 1 (309.8 ?± 9.4 mOsm, 38.9 ?± 1.1, and 0.7 ?± 1.1, respectively) than in group 2 (292.7 ?± 7.7 mOsm, 4.2 ?± 0.3, and 0.1 ?± 0.3, respectively; p<0.01 for all). TBUT was significantly lower in group 1 (8.7 ?± 3.6 s) than in group 2 (18.1 ?± 2.8 s; p<0.001). No significant differences were detected in Schirmer I test values between the groups (16.2 ?± 2.5 mm in group 1 and 16.6 ?± 2.3 mm in group 2; p=0.629). Conclusions: The results of this study showed that psoriasis may influence tear osmolarity and tear film function. Patients with psoriasis showed tear hyperosmolarity and tear film dysfunction.
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机译：目的：本研究的目的是评估牛皮癣患者的泪液渗透压，泪膜功能和眼表变化。方法：使用眼表疾病指数（OSDI）问卷，Schirmer I检验，泪膜断裂-正常运行时间（TBUT）测试，使用改良的Oxford量表对眼表荧光素染色进行评分以及泪液渗透压测量。结果：第一组的撕裂渗透压值，OSDI和牛津量表评分分别显着高于第二组（分别为309.8±9.4 mOsm，38.9±1.1和0.7±±1.1）（292.7±±7.7 mOsm，4.2）。分别为±0.3和0.1±0.3;对于所有的情况，p ＜0.01。第1组的TBUT（8.7±3.6 s）显着低于第2组的（18.1±2.8 s; p <0.001）。各组之间在Schirmer I测试值中未发现显着差异（第1组为16.2±2.5 mm，第2组为16.6±±2.3 mm; p = 0.629）。结论：本研究结果表明牛皮癣可能影响泪液渗透压和泪膜功能。牛皮癣患者表现为高渗性眼泪和泪膜功能障碍。
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