Aims and Objectives: To determine histopathologi-cal pattern of endometrium in patients with abnormal uterine bleeding. Study Type: Observational, Cross sectional. Place of Study: Obs and Gynae department, Madina teaching hospital, FSD. Duration of Study: One and a half year from Oct 2008 to Apr 2010. Patients and Methods: Patients presenting to Madina teaching hospital OPD with complaint of abnormal uterine bleeding were assessed via inclusion and ex-clusion criteria to be included in this study. A detailed history was followed by general physical, systemic, and gynecological examination. A pelvic ultrasound was performed followed by diagnostic D&C. Endo-metrial biopsy sent for histopathological examination in Pathology department of Madina teaching hospital, FSD. Data was collected over a period of one and a half year, and shifted to computer for analysis. Statisti-cal package of social sciences (SPSS) version 15 was used for statistical analysis of data. Chi-square good-ness of fit was used as test of statistical significance. Results: The most common pathological pattern iden-tified was proliferative phase endometrium (46.4%). Secretary phase endometrium was second most common pathology (37.6%). Cystic (5.2%), adenomatous (3.8%), and atypical (3.6%) hyperplasia constituted 12.6% of bulk. In 1.4%, endometritis was identified as a cause of abnormal uterine bleeding followed by atrophic endometrium (1%). Polyp was identified in 0.6% of cases followed by endometrial carcinoma (0.4%). Conclusion: Histopathological pattern of endomet-rium in patients with abnormal uterine bleeding is qui-te variable regardless of age, parity and ethnicity. Al-though the incidence of endometrial hyperplasia is grossly variable, yet incidence of endometrial carci-noma is small in all sited studies. Key words: D&C, AUB.
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