A REVIEW ON RESEALED ERYTHROCYTE AS A NOVEL DRUG DELIVERY SYSTEM

摘要

Cellular carriers possess great potential and merits in various modules of drug delivery. Among such cellular carriers, erythrocytes have been found to possess huge merits for the targeted and controlled drug delivery since they are non-immunogenic, non-toxic and their circulation can be readily controlled and could be manipulated with reference to time. Erythrocytes mediated drug delivery has been reported with therapeutic enzymes and antiviral agents to maximize therapeutic performance, reduce the side effects, as circulating depots for controlled drug release, drug targeting, treatment of parasitic diseases, hepatic tumors, removal of toxic agents etc. In this review, isolation of carrier erythrocytes, methods of drug loading, characterization parameters methods and clinical applications of resealed erythrocytes were presented.