Relationship between Anthropometric indices, serum Leptin and Respiratory function in Myanmar male adult subjects

摘要

Background: The role of leptin in respiratory function has been studied in specific respiratory disease. A little is known about the association of serum leptin level and respiratory function parameter in healthy subjects. Aims and Objectives: This study aimed to investigate the relationship between anthropometric indices, serum leptin and respiratory function in Myanmar male adult subjects Material and Methods: A community- based cross-sectional comparative study was carried out in 101 apparently healthy male adult subjects of age 18-45 years. All participants were categorized by anthropometric indices into non- obese (body mass index: BMI 2/sup and obese subjects (BMI 30 Kg/msup2/sup). Differences in respiratory function parameter and serum leptin level were compared across the group. Spirobank II spirometer was used to measure respiratory function (FEVsub1/sub, FVC, FEVsub1/sub/FVC, PEFR and FEFsub25-75%/sub). Serum leptin level was investigated by enzyme-linked immunosorbent assay. Results: The percentage of predicted value of all respiratory function parameters of obese group was significantly lower than that of non-obese group (p 1/sub/FVC, PEF and FEFsub25-75%/sub). Conclusion: Respiratory function declined with increasing anthropometric indices might be due to increased serum leptin level considered as systemic inflammatory effect of body.