SERUM ANTIOXIDANTS AS PREDICTORS OF ADULT RESPIRATORY DISTRESS SYNDROME

摘要

At the initial diagnosis of sepsis (6-24h before the development of ARDS), serum manganese superoxide dismutase (MnSOD) levelsand catalase activities are increased in septic patients who subsequently developed ARDS compared to septic patients who did not developARDS. Increases in MnSOD and catalase may be used to predict the occurrence of ARDS in septic patients with the same sensitivity,specificity and efficiency as parallel assessments of serum lactate dehydrogenase (LDH) and Factor VIII levels. Evaluation of serum MnSODand catalase as well as these other accessible markers facilitates identification of subsets of patients and allow prospective treatment ofseptic patients who are destined to develop ARDS.